S: EMA – http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/general/general_content_000330.jsp&mid=WC0b01ac058002956b (last access: 8 December 2015); FDA – http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm261078.pdf (last access: 8 December 2015).
N: 1. – drug (n): Middle English drogge. First Known Use: 14th century.
– substance (n): Middle English, from Anglo-French, from Latin substantia, from substant-, substans, present participle of substare to stand under, from sub- + stare to stand.
2. An active ingredient intended to furnish pharmacologic activity or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the body; it does not include intermediates used in the synthesis of such an ingredient.
S: 1. MW – http://beta.merriam-webster.com/dictionary/drug; http://beta.merriam-webster.com/dictionary/substance (last access: 8 December 2015). 2. TFD – http://medical-dictionary.thefreedictionary.com/Drug+Substance (last access: 8 December 2015).
SYN: active principle, active ingredient, drug, medicament, medicinal substance, therapeutic ingredient. (depending on context)
S: Cofepris – http://www.cofepris.gob.mx/Documents/Bibliografias/Medicamentos/Glosario.PDF (last access: 8 December 2015)
CR: amphetamine, antiaggregant, contraceptive, drug, drug product, hallucinogen, LSD, medication, methylenedioxymethamphetamine, narcotic (2), psychotropic drug, sleeping pill. target cell.