GC: n

S: WOL – https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-0004.2004.00315.x  (last access: 26 November 2020); SDir – https://www.sciencedirect.com/science/article/pii/B9780444627025000184  (last access: 26 November 2020).

N: 1. It was first used in 1902. This word comes from Modern Latin and Greek progeros (pro- means “before, sooner”; and geros means “old man”). It also has the abstract ending -ia.
2. A condition in which normal development in the first year is followed by gross retardation of growth, with a senile appearance characterized by dry wrinkled skin, total alopecia, and bird-like facies.
3. Progeria is caused by a mutation (change) in the lamin A (LMNA) gene. This gene makes a protein that holds the nucleus of a cell together. Because of the change in the gene, the protein becomes defective. This makes the nucleus unstable, which is believed to cause the premature aging process.
4. Children with progeria begin to show signs and symptoms of rapid aging within the first two years of life. These include: failure to grow at the same rate as their peers, loss of body fat, baldness, skin takes on an aged, wrinkled look and stiff joints.

S: 1. OED – https://www.etymonline.com/search?q=progeria (last access: 26 November 2020). 2. TERMIUM – https://www.btb.termiumplus.gc.ca/tpv2alpha/alpha-eng.html?lang=eng&i=1&srchtxt=progeria&codom2nd_wet=1#resultrecs (last access: 26 November 2020). 3&4. CC – https://my.clevelandclinic.org/health/diseases/17850-progeria (last access: 26 November 2020).

SYN: Hutchinson-Gilford syndrome, premature senile syndrome, Hutchinson-Gilford disease.

S: TERMIUM – https://www.btb.termiumplus.gc.ca/tpv2alpha/alpha-eng.html?lang=eng&i=1&srchtxt=progeria&codom2nd_wet=1#resultrecs (last access: 26 November 2020); GDT – http://gdt.oqlf.gouv.qc.ca/ficheOqlf.aspx?Id_Fiche=8372762 (last access: 27 November 2020).

CR: dwarfism