GC: n
S: MAYO – https://www.mayoclinic.org/diseases-conditions/primary-sclerosing-cholangitis/symptoms-causes/syc-20355797 (last access: 2 August 2021); MEDLP – https://medlineplus.gov/genetics/condition/primary-sclerosing-cholangitis/ (last access: 2 August 2021).
N: 1. – primary early 15c., primarie, ‘earliest, most basic, first in time or sequence’; 1560s, ‘from Latin primarius ‘of the first rank, chief, principal, excellent,’ from primus “first”.
– sclerosing (v.): Present participle of sclerose (from Ancient Greek σκλήρωσις, sklḗrōsis)
– cholangitis (n.): Composed of the word cholang (from Greek χολή) + angio- (from Ancient Greek ἀγγεῖον, angeîon, ‘vessel, urn, pot’) and suffix “-itis” (in medicine denoting ‘diseases characterized by inflammation’, from Greek –itis, feminine of adjectival suffix –ites ‘pertaining to’).
2. Primary sclerosing cholangitis (PSC) is a rare, heterogeneous, idiopathic, inflammatory disorder of the bile ducts resulting in strictures of the intrahepatic and/or extrahepatic bile ducts.
3. Patients with PSC are at risks of liver fibrosis, malignant complications (cholangiocarcinoma, colorectal adenocarcinoma, and gallbladder carcinoma), hepatic osteodystrophy complications (osteoporosis), nonmalignant outcomes (dominant stricture, occur with a cumulative frequency of 36 to 57 % of patients with PSC) and bacterial cholangitis.
4. The exact cause of PSC has not yet been established, but it is believed to be multifactorial. There is a strong association to genetic variants within the HLA-region on chromosome 6 is observed
S: 1. OED – https://www.etymonline.com/search?q=primary, https://www.etymonline.com/word/-itis (last Access 23 April 2021); Wiktionnary – https://en.wiktionary.org/wiki/sclerosing, https://en.wiktionary.org/wiki/sclerose#English (last Access 23 April 2021). 2&3. Forman, L. M. – https://link-springer-com.ezproxy.universidadeuropea.es/content/pdf/10.1007%2F978-3-319-40908-5.pdf (last Access 24 April 2021)
4. ORPHANET – https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=171&lng=EN (last Access 24 April 2021)
SYN: PSC, primary sclerosing cholangitis.
S: GDT – http://gdt.oqlf.gouv.qc.ca/ficheOqlf.aspx?Id_Fiche=8391718 (last Access 23 April 2021); TERMIUM PLUS – https://bit.ly/2S2puBF (last Access 23 April 2021).
