GC: n
S: https://www.nlm.nih.gov/medlineplus/druginfo/meds/a689002.html (last access: 4 February 2016); http://www.medicinenet.com/diclofenac/article.htm (last access: 4 February 2016).
N: 1. From IUPAC: 2-{2-((2,6-dichlorophenyl)amino)phenyl}acetic acid.
2. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). This medicine works by reducing substances in the body that cause pain and inflammation.
Diclofenac is used to treat mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis. The Cataflam brand of this medicine is also used to treat menstrual cramps.
Diclofenac powder (Cambia) is used to treat a migraine headache attack. Cambia will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
3. Oral diclofenac tablets, which are used for short-term pain relief, will no longer be available as an over-the-counter (OTC) pharmacy medicine in the UK from 15 January 2015 because of a small risk of heart problems, the Medicines and Healthcare products Regulatory Agency (MHRA) has announced.
Diclofenac was switched to a pharmacy (P) medicine in 2008, but in August 2013, the MHRA consulted on whether it should revert to a prescription-only medicine (POM) following a European review that found there was a small but significant increased risk of cardiovascular side effects associated with the drug.
4. Common names: voltaren rapide, delimon, orthofen, allvoran, vurdon, ecofenac, dicrofenac, ProSorb-D, feloran, prophenatin.
S: 1. http://www.chemicalize.org/structure/#!mol=Diclofenaco (last access: 4 February 2016). 2. http://www.drugs.com/diclofenac.html (last access: 4 February 2016). 3. http://www.pharmaceutical-journal.com/news-and-analysis/news/risk-of-heart-problems-prompts-removal-of-otc-diclofenac-from-uk-pharmacy-shelves/20067579.article (last access: 4 February 2016). 4. http://www.chemicalize.org/structure/#!mol=Diclofenaco (last access: 4 February 2016).
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