antifungal
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GC: n

S: NHS – https://www.nhs.uk/conditions/antifungal-medicines/ (last access: 15 November 2018); Patient – https://goo.gl/SK3JtQ (last access: 15 November 2018).

N: 1. From anti- (word-forming element of Greek origin meaning “against, opposed to, opposite of, instead,”) + fung- (from fungus, “a mushroom,” from Latin fungus “a mushroom, fungus;” used in English at first as a learned alternative to mushroom (funge was used in this sense late 14c; the Latin word is believed to be cognate with (or derived from) Greek sphongos, the Attic form of spongos “sponge”; “Probably a loanword from a non-IE language, borrowed independently into Greek, Latin and Armenian in a form *sphong- ) + -al (suffix forming adjectives from nouns or other adjectives, “of, like, related to, pertaining to,” Middle English -al, -el, from French or directly from Latin –alis).

  • As an adjective: capable of destroying fungi.

2. An antifungal is an agent that is destructive to fungi, suppresses the growth or reproduction of fungi, or is effective against fungal infections.
3. The excessive use of antifungal agents, compounded by the shortage of new drugs being introduced into the market, is causing the accumulation of multi-resistance phenotypes in many fungal strains. Consequently, new alternative molecules to conventional antifungal agents are urgently needed to prevent the emergence of fungal resistance. For example, Cateslytin (Ctl), a natural peptide derived from the processing of Chromogranin A, has already been described as an effective antimicrobial agent against several pathogens including Candida albicans. In the study: D-Cateslytin: a new antifungal agent for the treatment of oral Candida albicans associated infections has been compared that the antimicrobial activity of two conformations of Ctl, L-Ctl and D-Ctl against Candida albicans. The results show that D-Ctl and L-Ctl were potent and safe antifungal agents.

S: 1. OED – https://goo.gl/7k6ogS; https://goo.gl/2NEQbm; https://goo.gl/76qJN7 (last access: 19 November 2018); VOCAD – https://goo.gl/iiozrd (last access: 15 November 2018). 2. TERMIUM PLUS – https://goo.gl/HLA38Z (last access: 15 November 2018). 3. NCBI – https://goo.gl/LBhbx1 (last access: last access: 15 November 2018).

SYN: anti-fungal agent, antifungal agent, antimycotic, antimycotic agent, fungicide.

S: TERMIUM PLUS – https://goo.gl/HLA38Z (last access: 15 November 2018); VOCAD – https://goo.gl/iiozrd (last access: 15 November 2018).

CR: aspergillosis, bacterium, biodegradation, candidiasis, fungicide, fungus, microorganism, mycosis, parasitepathogen, pathogenic, virus, zygomycosis.