Alexander disease
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GC: n

S: NCBI – https://www.ncbi.nlm.nih.gov/books/NBK1172/ (last access: 20 March 2017); NIH – https://ghr.nlm.nih.gov/condition/alexander-disease (last access: 20 March 2017).

N: 1. – Alexander (pn): Alexander disease is named after the physician who first described the condition in 1949 (WS Alexander)
– disease (n): Early 14c., from Old French desaise (‘discomfort, inconvenience’), des– (‘dis = without, away’) + –aise (‘ease = physical comfort, undisturbed state of the body; tranquility, peace of mind’).
2. An infantile form of leukodystrophy, characterized by a collection of eosinophilic material at the surface of the brain and around its blood vessels, resulting in brain enlargement. It also causes macrocephaly, seizures, and spasticity.
3. Other names: Alexander’s disease, ALX, AxD, demyelinogenic, leukodystrophy, dysmyelinogenic leukodystrophy, fibrinoid degeneration of astrocytes and leukodystrophy with Rosenthal fibers.
4. Cultural Interrelation: Mentioned in House, M.D./Babies & Bathwater (episode 18, season 1).

S: 1. Webmd – http://www.goo.gl/2GCQpa (last access: 20 March 2017); OED – http://www.goo.gl/NwSTnL ; http://www.goo.gl/YwGHxZ (last access: 20 March 2017). 2. TFD – http://www.goo.gl/xNiGgK (last access: 20 March 2017). 3. GHR – http://www.goo.gl/cW6t94 (last access: 20 March 2017); NCBI – http://www.goo.gl/dyRx8q (last access: 20 March 2017). 4. TMH p. 63; http://tviv.org/House,_M.D./Babies_%26_Bathwater (last access: 1 March 2018).

SYN: dysmyelogenic leukodystrophy, dysmyelogenic leukodystrophy-megalobare, fibrinoid degeneration of astrocytes, fibrinoid leukodystrophy, hyaline panneuropathy, leukodystrophy with rosenthal fibers, megalencephaly with hyaline inclusion, megalencephaly with hyaline panneuropathy.

S: NORD – https://rarediseases.org/rare-diseases/alexander-disease/ (last access: 20 March 2017)

CR: epilepsy