S: http://www.infoplease.com/dictionary/brewers/acme.html (last access: 22 March 2016); http://study.com/academy/lesson/progress-of-disease-infection-to-recovery.html (last access: 22 March 2016).
N: 1. “highest point,” 1560s, from Greek akme “(highest) point, edge; peak of anything,” from PIE root *ak- “sharp” (see acrid). Written in Greek letters until c. 1620. The U.S. grocery store chain was founded 1891 in Philadelphia, Pennsylvania.
ACME (Gr. α̉κμή, point), the highest point attainable; first used as an English word by Ben Jonson.
2. The critical stage or crisis of a disease.
3. As nouns the difference between disease and acme is that disease is (pathology) an abnormal condition of the body or mind that causes discomfort or dysfunction; distinct from injury insofar as the latter is usually instantaneously acquired while acme is the top or highest point; pinnacle; culmination.
As a verb disease is (obsolete) to cause unease; to annoy, irritate.
4. Cultural Interrelation: What Does ACME Mean?
S: 1. OED – http://www.etymonline.com/index.php?term=acme (last access: 22 March 2016); https://en.wikisource.org/wiki/1911_Encyclop%C3%A6dia_Britannica/Acme (last access: 22 March 2016). 2. http://medical-dictionary.thefreedictionary.com/acme – Dorland’s Medical Dictionary for Health Consumers. © 2007 by Saunders (last access: 22 March 2016). 3. http://the-difference-between.com/acme/disease (last access: 22 March 2016). 4. http://acme.com/what_is_acme/ (last access: 22 March 2016).