GC: n S: http://emedicine.medscape.com/article/332244-overview (last access: 17 July 2015); http://www.healthline.com/health/systemic-lupus-erythematosus#Overview1 (last access: 17 July 2015). N: 1. systemic (adj): 1803, irregularly formed from system + -ic; used in medicine and biology for differentiation of meaning from systematic. Related: Systemically. lupus (n): late 14c., used of several diseases that cause ulcerations