Guillain-Barré syndrome

GC: n

S: MEDLP – (last access: 2 April 2017); WHO – (last access: 9 March 2018)

N: 1. – Guillain (pn): Georges Guillain (1876–1961) and on 1927 he used the name “Guillain–Barré syndrome” during a neurology congress.
– Barré (pn): On 1916, Jean Alexander Barré (1880–1967) met Guillain, who became head of the Neurology Centre of the sixth French Army.
– syndrome (n): “A number of symptoms occurring together,” 1540s, from medical Latin, from Greek syndrome “concurrence of symptoms, concourse of people,” from syndromos “place where several roads meet,” literally “a running together, from syn‘- “with” + dromos “a running, course”. Psychological sense is from 1955.
2. Acute inflammatory demyleinating polyradiculopathy Neurology A peripheral neuropathy of abrupt onset which follows a precipitating event–eg, a viral infection–eg, with HIV, HBV, EBV, or Camplyobacter jejuni, vaccination, bee stings, sarcoidosis, leukemia, lymphoma Clinical Rapidly ascending weakness of all 4 extremities with involvement of respiratory, facial, and bulbar muscles, with sparing of sphincter muscles Management Supportive, meticulous pulmonary hygiene, physical therapy, aggressive management of ulcers Prognosis Generally good with few sequelae in those who respond to therapy.
3. The exact cause of Guillain-Barre syndrome is unknown. But it is often preceded by an infectious illness such as a respiratory infection or the stomach flu.
4. There is no known cure for Guillain-Barré syndrome. However, there are therapies that lessen the severity of the illness and accelerate the recovery in most patients. There are also a number of ways to treat the complications of the disease.
5. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur.
6. In the context of Zika virus infection, unexpected increase in cases of Guillain-Barré syndrome has been described in affected countries. The most likely explanation of available evidence from outbreaks of Zika virus infection and Guillain-Barré syndrome is that Zika virus infection is a trigger of Guillain-Barré syndrome.
7. Cultural Interrelation: We could mention episode 16 Safe from the TV series (2004-2012) House M. D. (season 2).

S: S: 1. OED – (last access: 2 April 2017); NCBI – (last access: 23 May 2017). 2. MEDICALDICT – (last access: 2 April 2017); NCBI – (last access: 5 April 2017). 3. MAYO – (last access: 2 April 2017). 4. NINDS – (last access: 2 April 2017). 5. TERMIUM PLUS – (last access: 5 April 2017). 6. WHO – (last access: 9 March 2018). 7. (last access: 9 March 2018).

SYN: acute idiopathic polyneuritis, acute inflammatory polyneuropathy, infectious polyneuritis, Landry paralysis, Landry syndrome, Landry-Guillain-Barré syndrome, postinfectious polyneuritis.

S: MEDICALDICT – (last access: 5 April 2017)

CR: paresthesia, Zika virus