Whipple’s disease

GC: n

S: MNT - http://www.medicalnewstoday.com/articles/188228.php(external link) (last access: 30 March 2017); NCBI - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC88990/(external link) (last access: 4 April 2018).

N: 1. - Whipple (pn): George Hoyt Whipple (1878 - 1976), American pathologist whose discovery that raw liver fed to chronically bled dogs will reverse the effects of anemia led directly to successful liver treatment of pernicious anemia by the American physicians George R. Minot and William P. Murphy. This major advance in the treatment of noninfectious diseases brought the three men the Nobel Prize for Physiology or Medicine in 1934.
- disease (n): Early 14c., from Old French desaise (‘discomfort, inconvenience’), des- (‘dis = without, away’) + -aise (‘ease = physical comfort, undisturbed state of the body; tranquility, peace of mind’).
2. Whipple's disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. Caused by the bacterium Tropheryma whipplei, the disorder can affect any system in the body, including the brain, eyes, heart, joints, and lungs, but usually occurs in the gastrointestinal system.
3. Gastrointestinal signs and symptoms are common in Whipple disease and may include: diarrhea, abdominal cramping and pain, which may worsen after meals weight loss, associated with the malabsorption of nutrients.
Other frequent signs and symptoms associated with Whipple disease include:
inflamed joints, particularly the ankles, knees and wrists, fatigue, weakness,
4. Cultural Interrelation: We could mention Private Lives, a 6th season episode of House which first aired on March 8, 2010. Final Diagnosis: Whipple's disease.

S: 1. EncBrit - https://www.britannica.com/biography/George-Whipple(external link) (last access: 21 March 2017); OED - http://www.etymonline.com/index.php?term=disease&allowed_in_frame=0(external link) ; http://www.etymonline.com/index.php?term=ease&allowed_in_frame=0(external link) (last access: 17 March 2017). 2. NINDS - https://www.ninds.nih.gov/disorders/all-disorders/whipples-disease-information-page(external link) (last access: 21 March 2017). 3. MAYO - http://www.mayoclinic.org/diseases-conditions/whipples-disease/basics/symptoms/con-20025442(external link) (last access: 21 March 2017). 4. http://house.wikia.com/wiki/Private_Lives(external link) (last access: 6 May 2018).

SYN: intestinal lipodystrophy, intestinal lipophagic granulomatosis, secondary non-tropical sprue, malabsorption syndrome.

S: WebMD - http://www.webmd.com/ibd-crohns-disease/whipple-disease(external link) (last access: 29 March 2017)

CR: bacterium


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