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rifampicin

GC: n

S: http://www.patient.co.uk/medicine/rifampicin(external link) (last access: 12 March 2013); NAVARRO p. 875

N: 1. Rifampicin is a semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160).
2. Not to be confused with rifamycine.
3. Cultural Interrelation: The name “rifamycin” refers to the popular 1955 French film noir movie Rififi. In 1965, rifampicin, a hydrazone of a rifamycin B derivate with N-amino-N′-methylpiperazine, proved to be well absorbed orally and retained its highly bactericidal action.

S: 1. https://pubchem.ncbi.nlm.nih.gov/compound/Rifampicin#section=Top(external link) (last access: 18 May 2016). 2. NAVARRO p. 875; FCB. 3. http://cid.oxfordjournals.org/content/52/9/e194.full(external link) (last access: 5 April 2015).

SYN: 1. rifampicinum (n) (GB), 2. rifampin (n) (US)

S: 1 & 2. GDT (last access: 12 March 2013). 2. NAVARRO p. 875

CR: tuberculosis (EN)

Terminology

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